ERA-CVD project SCAN beginning soon!
Subclinical atherosclerosis characterization: Nanoparticle-based molecular and cellular imaging
Jacob Fog Bentzon, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
Susanne Feil, University of Tübingen, Tübingen, Germany
Mangala Srinivas, Radboud University Medical Centre, Nijmegen, The Netherlands
Molecular imaging of atherosclerosis can become a key tool to understand progression of atherosclerosis to clinical disease; identify persons that need preventive therapy; test the causal role of risk factors; and guide the development of new drugs.
Partners in the present project have recently found that smooth muscle cells contribute a larger proportion of cells in atherosclerosis than previously thought, and have developed two nanoparticle technologies that allow imaging across a range of modalities. In SCAN this knowledge and technology is brought together to develop multimodal imaging of atherosclerosis with nanoparticles targeted to smooth muscle cells.